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3D-STE feasibility differed by ethnicity, being lowest in South Asian participants and highest in African Caribbean participants (p less then 0.0001). Similar trends were observed in men (P less then 0.0001) and women (P = 0.005); however, in South Asians, there were more women with unreadable 3D-images compared to men (67 vs. 58%). Intra- and inter-observer variabilities were excellent for most of conventional and advanced echocardiographic measures. The test-retest reproducibility was good-excellent and fair-good for conventional and