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Ferritin levels were significantly correlated with the severity of depressive symptoms (r = -0.22; = 0.04) and quality of life assessment (r = 0.22; = 0.04) in the MS patients. Moreover, the severity of fatigue and depressive symptoms was significantly linked to a deterioration in quality of life. Ferritin deficiency in MS patients is associated with an exacerbation of depressive disorders and a decline in quality of life. Symptoms of fatigue in MS patients are inversely proportional to mood and quality of life. Ferritin deficiency in MS p