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Background/aim Although regular management of cetuximab may be the standard routine in customers with metastatic colorectal cancer tumors (mCRC), the effectiveness and security of a biweekly routine is a pending issue. We carried out this meta-analysis examine the efficacy and security of a biweekly vs. a weekly regimen of cetuximab in the remedy for mCRC. Customers and methods We carried out a thorough electric literature search as much as January 2020 to identify studies straight contrasting the effec