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This work supports the hypothesis that low vitamin D levels can exacerbate pre-existing ophthalmic conditions such as diabetes. © 2020 by the American Diabetes Association.MG53 is a member of the TRIM protein family that is predominantly expressed in striated muscles and participates in cell membrane repair. Controversy exists regarding MG53's role in insulin signaling and manifestation of diabetes. We generated db/db mice with either whole-body ablation or sustained elevation of MG53 in the bloodstream in order to evaluate the physiolo
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