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Together, our results suggest the involvement of two distinct pathways in type I interferon signaling upon DNA damage. Moreover, radiation plus ATR inhibition may be a promising new combination therapy against cancer.Nodular prurigo (NP) is a clinical description of characteristic secondary skin changes -excoriations and nodules- in response to pruritus. The underlying cause is unclear, but up to 80% of patients have atopy and a smaller number have systemic disease e.g. chronic renal failure, iron deficiency or HIV (1). Increased numbers