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Treatment of Add Treatment of add usually involves medication and psychosocial treatments. Treatments for ADHD can include stimulants, such as methylphenidate and amphetamine compounds or nonstimulant medications such as atomoxetine (Strattera), bupropion (Wellbutrin) and tricyclic antidepressants. Clonidine, a mood stabilizer, and guanfacine (Catapres, Kapvay) can be used to treat an underlying mood disorder. Stimulants Stimulants act on the central nervous system to increase the level of alertness