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Background Differences in imaging parameters influence computer-extracted parenchymal enhancement measures from breast MRI. Purpose To investigate the effect of differences in dynamic contrast-enhanced MRI acquisition parameter settings on quantitative parenchymal enhancement of the breast, and to evaluate harmonization of contrast-enhancement values with respect to flip angle and repetition time. Study type Retrospective. Phantom/populations We modeled parenchymal enhancement using simulations, a phantom, and two cohorts (N = 398 and N =