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Using higher concentration of F. carica latex and with longer treatment lengths may increase its efficacy in the treatment of CL.  0.05). The findings of the current study demonstrated that the 5% F. carica latex with a 3-week course of treatment had no considerable effect in recovery or control of CL induced by L. major in the murine model. Using higher concentration of F. carica latex and with longer treatment lengths may increase its efficacy in the treatment of CL. A chronic state of imbalance between effort and reward can affect slee