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In this research, we report six unique instances of clients impacted by BBSOAS (Boonstra-Bosch-Schaff optic atrophy syndrome), a newly growing uncommon neurodevelopmental condition, brought on by loss-of-function mutations regarding the transcriptional regulator NR2F1. Younger clients with NR2F1 haploinsufficiency display mild to moderate intellectual disability and program reproducible polymicrogyria-like brain malformations into the parietal and occipital cortex. Making use of a recently