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Saffron-derived crocetin (Crt) and crocin (Cro) utilizing the known anticancer activity, have shown hypolipidemic effect in diabetes and atherosclerosis. Here, we investigated the result of Crt/Cro on lipid content in breast disease. studies was applied. The 4T1-induced cancer of the breast in mice had been utilized to research the end result of Crt/Cro on cholesterol (Chl) and triglyceride (TG) levels in serum and cyst cells. The Chl/TG amounts had been also considered into the cytosol of MDA