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Copyright© Bentham Science Publishers; For any questions, please email at epub@benthamscience.net.BACKGROUND Colorectal Cancer (CRC) the most common deadly diseases with a high morbidity. Alteration associated with the sugar k-calorie burning is one of the hallmarks into the improvement CRC. The Glucose Transporter 1 (GLUT1) is an integral rate-limiting necessary protein in hyperactive sugar k-calorie burning and up-regulated in CRC, however, the underlying system of this changed metabolism