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In the present research, we aimed to establish a link between the molecular framework of commonly used polar lipids and medication solubilization in biorelevant news. The solubilization of fenofibrate by 13 phospholipids, 11 efas and 2 monoglycerides had been studied by an in vitro type of the upper GI region. The main trends were verified with progesterone and danazol. It was uncovered that to change drug solubilization in biorelevant news, the