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Adult ADHD and Comorbid Disorders Many people with ADHD have comorbid disorders like major depression (Kessler et al 2006). Many depressed patients do not respond well to medication and could benefit from therapy. Medications that most effectively improve core symptoms of ADHD appear to increase and regulate levels of certain brain chemicals called neurotransmitters. Drugs that stimulate the brain such as methylphenidate or amphetamine are commonly prescribed. Medicines Adults can use many medications that are u