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Osteoarthritis (OA) is a broad osteo-arthritis. Cartilage damage is related to a decrease in the density of chondrocytes. Mesenchymal stem cells (MSCs) differentiate into adipocytes, osteocytes and chondrocytes, and tend to be loaded with cellular therapy. Cartilage-derived extracellular matrix (ECM) promotes chondrogenesis of MSCs. Nonetheless, the part of MSCs stimulated by ECM is not distinguished in OA. The objective of this research will be determine the part of particular facets crea