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The aim of the present study was to assess the value of panendoscopy of the upper aero-digestive tract in the identification of synchronous tumors in OSCC patients without clinical signs of a second primary tumor. In this retrospective study, patients diagnosed with a primary OSCC who received surgical therapy between January 1 , 2012 and December 31 , 2017 were included. Participants must have undergone panendoscopy during the staging process. None of these patients showed clinical signs of a second primary tumor. A total of 265 patients (