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These structural models provide insights into stability for different turns and twists corresponding to non-regular folds in protein hotspots. This journal is © The Royal Society of Chemistry 2019.Photodynamic therapy is considered as a promising treatment for cancer, but still faces several challenges. The hypoxic environment in solid tumors, imprecise tumor recognition and the lack of selectivity between normal and cancer cells extremely hinder the applications of photodynamic therapy in clinics. Moreover, the "always on" property of ph
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