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Wrinkling occurs on the surfaces of large-area graphene ubiquitously. Despite that the wrinkled structures are found to degrade the lubricous property, the behind mechanisms remain less understood. Here, atomic force microscopy is adopted to characterize the friction and wear properties of graphene wrinkles (GWs) with different heights by nanoscratch tests. We verify the phenomena of high friction and reduced load-carrying capacity of wrinkles and report the observation of lubrication deterioration with increased heights. Using molecular