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he long-term use of marijuana for sleep/relaxation. To review the use of Von Willebrand Factor (VWF) concentrate for treatment of acquired Von Willebrand syndrome (VWS)-related bleeding in adult extracorporeal membrane oxygenation (ECMO) patients and determine if it was associated with improved VWF laboratory parameters. Retrospective observational cohort study. Tertiary care academic medical center. Adult ECMO patients who received VWF concentrate for treatment of acquired VWS- related bleeding. None, observational study. Ten adult ECMO