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Adult ADHD and Comorbid Disorders Many people suffering from ADHD have comorbid conditions such as major depression (Kessler and co., 2006). Many depressed patients aren't able to take medication and could get better results from therapy. Medications that most effectively improve the symptoms of ADHD are those that boost and balance levels of specific neurotransmitters in the brain. The stimulants methylphenidate and amphetamine are often prescribed. Medicines Adults are able