https://www.selleckchem.com/pr....oducts/larotrectinib
05). Compared with the NOR group, the WB group showed higher formation of reactive oxygen species (P less then 0.05), increased level of oxidation products and antioxidant activities (P less then 0.05), accompanied with mitochondrial damages and lower mitochondrial membrane potential (P less then 0.05). Meanwhile, the relative mRNA expressions of Nrf2 and its downstream antioxidant genes including heme oxygenase-1 (HMOX1), NAD(P)H qui none dehydrogenase 1 (NQO1), Glutathione (GPX), superoxide dismutase (SOD) and glutamate-cysteine
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