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82; 95% confidence interval=1.07 to 3.11, P=.03; 10-year hazard ratio=1.24; 95% confidence interval=1.03 to 1.48, P=.02). Amongst patients with de-novo AHF, women had higher mortality rates compared with men. The observed gender-related differences in de-novo AHF patients highlight the need for further and deeper research in this field. Amongst patients with de-novo AHF, women had higher mortality rates compared with men. The observed gender-related differences in de-novo AHF patients highlight the need for further and deeper research