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To describe Brazilians' behavior regarding face mask use and health literacy during the COVID-19 pandemic before and after the Ministry of Health of Brazil formal recommendation. Cross-sectional surveys using a web-based questionnaire. Participants were recruited via snowball techniques. São Paulo state, the urban epicenter of the COVID-19 pandemic in Brazil at the time of the study. 2.203 clicks to the survey link and 1.223 surveys completed (55.5% response rate). However, only 1118 surveys were considered after the exclusion criteria