https://www.selleckchem.com/pr....oducts/sbi-0640756.h
First, we found that BCMA mice had more severe EAE compared with BCMA mice and the increased disease was associated with elevated anti-MOG B-cell responses. Second, we found that anti-CD20 therapy attenuated EAE in BCMA mice but not in BCMA mice. Third, TACI-Fc attenuated EAE in BCMA mice but not in BCMA mice. Mixed bone marrow chimeric and cell culture experiments demonstrated that BCMA deficiency elevates inflammatory B-cell responses but inhibits inflammatory responses in macrophages. BCMA has multifaceted roles during inflammati
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