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6% capacity utilization were attained for MabSelect SuRe LX resin under 5 g/L concentration at RTC = 2.8 min and s = 87.5%. Moreover, a simplified approach was suggested to obtain the optimal RTC for the maximum productivity. The results demonstrated that model-assisted tools are useful to determine the optimum conditions for 3C-PCC continuous capture with high productivity and capacity utilization.The aim of this study was to develop an automated segmentation approach for small gross tumor volumes (GTVs) in 3D planning computed tomogr