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Adult ADHD and Comorbid Disorders Many adults with ADHD suffer from comorbid disorders, like major depression (Kessler et al 2006). Many patients do not respond to medication for depression and may benefit from psychotherapy. The most effective medications to treat core symptoms of ADHD are those that boost and balance levels of certain brain chemicals called neurotransmitters. The most frequently prescribed stimulants include amphetamine, methylphenidate,
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