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011 and =0.0001,respectively). The HTLV-1 PVL was higher in ATL patients compared to with AC group ( =0.015). There was a significant increase in perforin gene expression in ACs compared with ATL patients ( =0.002). Furthermore, the expression of granzyme was also higher in ACs compared with ATL patients, and significant differences were observed between the two groups ( =0.036). Low expression of perforin and granzyme in ATL patients seems to influence the efficiency of CTL function and destruction of HTLV-1-infected cells, which might c
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