https://oicr-9429antagonist.co....m/advancements-from-
The components that underlie this neuropathy are not defined, and effective therapy and avoidance measures aren't readily available. Right here, we indicate that SIRT2 protected mice against cisplatin-induced peripheral neuropathy (CIPN). SIRT2 accumulated within the nuclei of dorsal root ganglion physical neurons and stopped neuronal cell death following cisplatin therapy. Mechanistically, SIRT2, an NAD+-dependent deacetylase, safeguarded neurons from cisplatin cytotoxicity by
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