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Collagen sort I (Col-I) is unique due to its excessive biocompatibility in human tissue. The acceptable physicochemical properties of native Col-I further improve the incorporation of Col-I in various fields, including pharmaceutical, cosmeceutical, regenerative medicine, and medical. The review is meant to offer particular information on Col-I at present out there, going back 5 years. This is expected to provide a helping hand for researchers who are concerned about any development on collagen-based merchandise notably for therapeutic fields