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This detection method showed the advantages of a fast response time, and high sensitivity and selectivity. The response time and the limit of detection were as low as 2 s and 103 pM, respectively, benefiting from the uniform cavities and the large specific surface area of Fe-TCPP-MOF, which ensure (1) uniform dispersion of the Au NPs on the surface of the cavity; and (2) a higher chance of interaction of mercury and MB owing to the gathering effect of Fe-TCPP-MOF.We present a reaction-based fluorescent probe (1) for Hg2+ and CH3Hg+, ba