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Functional status assessments of activities of daily living may improve prognostic precision during initial diagnostic evaluations in young and middle-aged adults with cancer. However, the association between pretreatment functional status and survival in these patients is poorly understood. This study aimed to evaluate the prognostic value of functional status in young and middle-aged patients with cancer. Multicentre retrospective cohort study. We used a cancer registry from Osaka Prefecture, Japan. The data were linked to administrat