https://www.selleckchem.com/products/A014418.html
A QT effect (ΔΔQTcF) exceeding 10 msec could be excluded within the observed concentration range at 160 mg and 480 mg doses. Assay sensitivity was established by moxifloxacin with 90% lower bound exceeding 5 msec. Implementing a C-QTc analysis prospectively in this TQT study resulted in a substantially smaller sample size to maintain a similar study power as shown in the traditional time-point analysis. A single 160-mg or 480-mg zanubrutinib dose did not prolong the QTc interval or have any other clinically relevant effects on ECG param
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