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A dramatic boost in CCS indicators the event of large-scale conformational changes in the protein and identifies the power limit, beyond which appropriate informative data on the protein-binding sections of heparin chains is unlikely to be gotten. Testing this approach using a 1 1 complex created by a recombinant type of an acidic fibroblast growth element (FGF-1) and a synthetic pentasaccharide GlcNS,6S-GlcA-GlcNS,3S,6S-IdoA2S-GlcNS,6S-Me as a model system in