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Endophthalmitis is a serious complication of cataract surgery that occurs in thousands of patients each year. To decrease the incidence of post-operative endophthalmitis, many surgeons inject intracameral antibiotics (cefuroxime, moxifloxacin, and vancomycin) routinely at the conclusion of surgery. A large number of recently published retrospective studies and large database analyses have reported decreased endophthalmitis rates with routine antibiotic use, and the only prospective, multi-center, randomized trial performed by the Europ