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u. Finally, in vitro experiments with spinal neurons exposed to astrocyte-conditioned media showed that modulation of S1P or cytokine signaling in astrocytes via BAF312 prevented neurons from astrocyte-induced degeneration. Overall, these experiments on human astrocytes suggest that during neuroinflammation targeting of S1P1 via BAF312 may modulate key astrocyte functions and thereby attain neuroprotection indirectly. Copyright © 2020 Colombo, Bassani, De Angelis, Ruffini, Ottoboni, Comi, Martino and Farina.The exosome serves as a trafficking vehicl