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uate the metabolic state of gallbladder lesions.BACKGROUND/AIMS The interaction of CD40 ligand (CD40L) and CD40 triggers the induction of pro-inflammatory cytokines. It has been proposed that vitamin D deficiency might be an important factor, which causes or aggregates the autoimmune situations. The aim of the present study was to assess the effect of vitamin D on CD40L gene expression in patients with ulcerative colitis (UC). MATERIALS AND METHODS Ninety mild-to-moderate UC patients were randomized to receive a single injection of 7.5 mg