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Background High parental educational attainment is protective against youth health risk behaviors such as tobacco use. According to the Marginalization-related Diminished Returns (MDRs) theory, however, higher parental education is less protective for marginalized groups relative to non-Hispanic Whites. Objective To explore race/ethnic differences in the effects of parental educational attainment on cigarette smoking in a national sample of American adolescents. Methods In a cross-sectional study, we used baseline data of 10,878 Ameri