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01). Average pain score for trial days 2-4 was higher for the pretreatment group compared with the misoprostol-only group (6.9 vs 6.0, p=0.01), and there was a trend toward shorter total duration of pain (15 vs 19 hours, p=0.08). These differences remained after controlling for treatment success across arms. Mifepristone pretreatment increased the severity of pain but not bleeding and resulted in a shorter trajectory of symptoms during medical management of EPL. Mifepristone pretreatment increased the severity of pain but not bleeding
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