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In this report, a 58-year-old patient presented with fever, generalized rash and systemic symptoms as immediate consultation to the Dermatology Clinic of Cagliari amidst the Italian outbreak in belated March 2020. After a poor nasopharyngeal swab for SARS-CoV-2, secondary syphilis had been verified by serological examinations and epidermis biopsy, underlining that, even during a worldwide pandemic, various other typical and imp