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Stem cell therapy seemed to be very effective in treating many, even beforehand incurable, diseases. The problem was that when scientists isolated ESCs within the lab, the embryo, which had potential for changing into a human, was destroyed (Fig. 8). Because of this, scientists, seeing a big potential on this remedy methodology, focused their efforts on making it attainable to isolate stem cells without endangering their source—the embryo. During the course of development from pluripotent hESCs to differentiated somatic cells, essential modif