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Pooled odds ratios (ORs) with 95per cent self-confidence periods (CIs) for the associations between PPI usage in addition to chance of CRC were projected with a fixed-effects or random-effects design. We identified and included 9 observational researches (3 cohort studies and 6 case-control studies) comprising 1,036,438 members. Overall, there clearly was no statistically significant organization between PPI use as well as the danger of CRC (pooled OR 1.26, 95% CI 0.90-1.73; p = 0.166) when PPI publi
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