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All materials caused dose- and time-dependent responses in the exposed mice. Nonetheless, all amounts of Bentonite caused bigger, but reversible, inflammation (BAL neutrophils) and acute stage reaction (Saa3 gene expression in lung) compared to the two ONC. Similarly, highest amounts of DNA strand breaks had been present in BAL cells of mice confronted with Bentonite 1 day post-exposure. An important increase of DNA strand pauses had been recognized also for