https://www.selleckchem.com/pr....oducts/gsk1120212-jt
The effects of PDGFR-β inhibitor and PI3K inhibitor were observed. Compared with group CON, group IMA, and group LY294002, α-SMA was upregulated in group PDGF-BB (p 0.05), with higher OD490 nm value (p 0.05), narrower average scratch width, and higher relative cell migration rate (p 0.05). The expression levels of Col I, p-PDGFR-β, p-PI3K, and p-AKT were higher in group PDGF-BB (p 0.05). PDGF-BB induces FB to transform into myofibroblasts (MF through the PDGFR-β/PI3K/AKT signaling pathway, and promotes the
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