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The biogenic volatile organic compounds (BVOCs) emissions are influenced by ambient ozone (O3) concentrations and vegetation cover. In most studies, however, the interaction between O3 and plants has not been considered and there are uncertainties in land cover input and emission factors (EFs) in BVOCs emission estimation, particularly at the regional scale. In this study, an O3 exposure-isoprene (ISOP) response function was developed using meta-analysis, and the EFs of ISOP and land cover inputs were updated by integrating local measure