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Adult ADHD and Comorbid Disorders Many adults with ADHD also have comorbid disorders like major depression (Kessler and colleagues, 2006). Many patients are not responsive to medication for depression and may benefit from psychotherapy. Treatments that are most effective in reducing the most fundamental symptoms of ADHD seem to boost and balance levels of certain brain chemicals called neurotransmitters. Stimulants such as methylphenidate and amphetamine are frequently prescribed. Medicines Adults can take a v