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This meta-analysis assessed the prognostic value and medical importance of claudin-1 in CRC. We retrieved qualified researches from PubMed, Cochrane Library, Embase, and internet of Science databases before February 10, 2020. The hazard ratio (HR) with 95per cent confidence interval (CI) ended up being applied to assess the correlation between claudin-1 and prognosis and clinical functions. Heterogeneity ended up being evaluated by the Cochran ), while publication p