https://www.selleckchem.com/pr....oducts/CP-690550.htm
0001), while either incubation of isolated atria with licofelone (a dual COX/5-LOX inhibitor) or injection of licofelone to animals could reverse it, completely (P less then 0.01). Hydrocortisone (phospholipase A2 and COX-2 inhibitor) in vitro and in vivo (P less then 0.001, P less then 0.05, respectively) as well as indomethacin (COX inhibitor) in vitro and in vivo (P less then 0.05, P less then 0.01, respectively) exerted some lesser effects. Our data revealed that in endotoxemic rats, chronotropic hyporesponsiveness to cholinergic
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