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MPP versus BiV delivered greater LVESV improvement (8.3% decrease in MPP vs. 10.3% increase in BiV patients, p=.047), greater increase in LVEF (7.7%vs. 1.8%, p=.008), and higher 0-12 month super-responder rate (86.4%vs. 56.0%, p=.027). More MPP vs. BiV patients experienced an improvement in NYHA (84.6%vs. 50.0%, p=.047) and EQ-5D (94.4%vs. 54.0%, p=.006). MPP with wide anatomical spacing in CRT responder patients resulted in improved LV reverse remodeling with higher rates of super-responders, and better quality of life metrics. MPP with