https://www.selleckchem.com/pr....oducts/tolebrutinib-
To investigate the protective effect of vanillin in cisplatin (CP)-induced nephrotoxicity in rats and elucidate the role of nrf-2 and its downstream antioxidant molecules. Rats received vanillin (100mg/kg orally) for 10 constitutive days and CP (7.5mg/kg, once, ip) on day 6 of vanillin administration. Cisplatin suppressed body weight gain, increased serum urea and creatinine and renal malondialdehyde and nitric oxide while decreased renal total antioxidant capacity. Up-regulation of NADPH oxidase-4 (NOX-4) was marked in r
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