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g pathologically proven HCC lesions not meeting LI-RADS criteria for definitive HCC (LR5) can correctly differentiate HCC lesions from other liver malignancies, potentially expanding the role of image-based diagnosis in primary liver cancer with atypical features. • The trained CNN demonstrated an overall accuracy of 87.3% and a computational time of less then  3 ms which paves the way for clinical application as a decision support instrument. Diagnosis of otosclerosis on temporal bone CT images is often difficult because the imaging find