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Led because of the modulated synthesis and isoreticular expansion strategy, five chiral Zr-MOFs with a flu or ith topology tend to be constructed from enantiopure 1,1'-biphenol-derived tetracarboxylate linkers and Zr6, Zr9, or Zr12 clusters. The received MOFs all reveal high chemical security in boiling-water, strongly acid, and weakly standard aqueous solutions. The two flu MOFs featuring the dihydroxyl sets of biphenol in open and large cages, aft